Orofacial Antinociceptive Effect of Nifedipine in Rodents Is Mediated by TRPM3, TRPA1, and NMDA Processes

• DOI: 10.11607/ofph.2491
• Publication Date: 2020-04-07T19:06:21Z
• Authors: Breytiner de Oliv...; Sacha Santos; Erik Pereira; Andressa Nogueira; Antônio Neto; José de Melo Júnior; Marina Damasceno; Lucindo Quintans-...; Barry Sessle; Francisco Magalhães; Adriana Campos
• Keywords: Orofacial Pain; Capsaicin

To test for the possible antinociceptive effect of nifedipine in rodent models acute and chronic neuropathic orofacial pain involvement TRP- NMDA-related processes this effect.Acute nociceptive behavior was induced by administering formalin, cinnamaldehyde, glutamate, capsaicin, or acidified saline to upper lip hypertonic cornea Swiss mice. Acute also formalin injected into TMJ mustard oil masseter muscle Wistar rats. The model involved infraorbital nerve transection (IONX) rats induce mechanical hypersensitivity, which assessed with von Frey hair stimulation lip. effects pretreatment vehicle (control) were tested on behaviors. Docking experiments performed. Statistical analysis included one-way ANOVA followed Tukey post hoc two-way Bonferroni (statistical significance P < .05).Nifedipine produced significant all behaviors except that capsaicin. attenuated NMDA, TRPA1, TRPM3 receptor antagonists. IONX animals developed facial significantly reduced nifedipine. docking suggested may interact NMDA receptors.The present study has provided novel findings a variety showing nifedipine, selective inhibitor L-type Ca2+ channels, can suppress through systems.