Functional Effects of the ABO Locus Polymorphism on Plasma Levels of von Willebrand Factor, Factor VIII, and Activated Partial Thromboplastin Time

• DOI: 10.1161/01.atv.20.8.2024
• Publication Date: 2011-06-17T19:44:19Z
• Authors: Juan Carlos Souto; Laura Almasy; Eduardo Muñiz-Diaz; José Manuel Soria; Montserrat Borrell; Laia Bayén; José Mateo; Pedro Madoz; William Stone; John Blangero; Jordi Fontcuberta
• Keywords: Thromboplastin

Lower levels of factor VIII and von Willebrand (vWF) have been reported in individuals with blood type O compared other ABO types. However, this relationship has demonstrated only by association studies not linkage studies. Also, it is clear whether the locus exerts a functional effect directly on these plasma factors or disequilibrium another that controls factors. To distinguish between 2 possibilities, we applied new statistical methods combining tests pedigree-based sample. In contrast to most previous used phenotypes, our study genotypes, permitting us AO from AA BO BB. Our results clearly showed significant vWF antigen (P=0.00075). addition, coagulant activity activated partial thromboplastin time suggestive (P=0.10 P=0.13). All 3 phenotypes differences OO non-OO genotypes. exhibited heterozygotes homozygotes. This unique because combined test, which indicated itself phenotypes.