Increased Platelet Binding to Circulating Monocytes in Acute Coronary Syndromes

• DOI: 10.1161/01.cir.0000015700.27754.6f
• Publication Date: 2002-07-28T23:16:47Z
• Authors: Jaydeep Sarma; Caterina A. Laan; Shirjel Alam; Ashwani Jha; Keith A.A. Fox; Ian Dransfield
• Keywords: Unstable angina; Monocyte; P-selectin

Background — Present therapies for acute coronary syndromes aim toward limiting platelet–platelet adhesion and aggregation processes. However, platelet–leukocyte interactions may contribute importantly to disease progression in the arterial wall. Recent studies suggest that prevention of binding via P-selectin glycoprotein ligand-1 (PSGL-1) be beneficial animal models vascular injury. Methods Results P-selectin–PSGL-1 were found account most platelet–monocyte observed peripheral blood samples from healthy donors. a significant component was calcium independent, involving neither PSGL-1 nor P-selectin. Platelet–monocyte examined 52 patients admitted within 14 hours symptom onset, with defined as unstable angina (n=12) myocardial infarction (n=13) or noncardiac chest pain (n=27). When compared pain, significantly elevated levels (70.1±15.4% versus 45.4±23.3%; P <0.01) (67.4±12.9% >0.01). Calcium-independent alone (14.7±7.7% 6.1±5.96%; <0.001). Conclusions There is evidence P-selectin–independent molecular conjugation blood. Patients demonstrate increased total platelets monocytes. Additionally, calcium-independent infarction. These findings novel cation-independent mechanisms mediate binding, representing new therapeutic target after injury associated