Low-T3 Syndrome

• DOI: 10.1161/01.cir.0000048124.64204.3f
• Publication Date: 2003-02-12T20:33:23Z
• Authors: Giorgio Iervasi; Alessandro Pingitore; Patrizia Landi; Mauro Raciti; Andrea Ripoli; Maria Scarlattini; Antonio L’Abbate; Luigi Donato
• Keywords: Dyslipidemia

Background— Clinical and experimental data have suggested a potential negative impact of low-T3 state on the prognosis cardiac diseases. The aim present prospective study was to assess role thyroid hormones in patient population with heart disease. Methods Results— A total 573 consecutive patients underwent function profile evaluation. They were divided two subgroups: group I, 173 low T3, ie, free T3 (fT3) <3.1 pmol/L, II, 400 normal fT3 (≥3.1 pmol/L). We considered cumulative death events. During 1-year follow-up, there 25 deaths I 12 II (14.4% versus 3%, P <0.0001); 13 6 (7.5% 1.5%, =0.0006). According Cox model, most important predictor (hazard ratio [HR] 3.582, <0.0001), followed by dyslipidemia (HR 2.955, =0.023), age 1.051, <0.005), left ventricular ejection fraction 1.037, =0.006). At logistic multivariate analysis, highest independent 0.395, =0.003). prevalence levels found NYHA class III-IV illness compared I-II (χ 2 5.65, =0.019). Conclusions— Low-T3 syndrome is strong might be directly implicated poor patients.