Coronary Restenosis After Sirolimus-Eluting Stent Implantation

• DOI: 10.1161/01.cir.0000083366.33686.11
• Publication Date: 2003-07-15T00:32:03Z
• Authors: Pedro A. Lemos; Francesco Saia; Jurgen M.R. Ligthart; Chourmouzios A. A...; Georgios Sianos; Kengo Tanabe; Angela Hoye; Muzaffer Degertekin; Joost Daemen; Eugene McFadden; Sjoerd Hofma; Pieter C. Smits; Pim de Feyter; Willem J. van der...; Ron T. van Domburg; Patrick W. Serruys
• Keywords: Sirolimus; Intravascular Ultrasound; Coronary stent

We describe the clinical and morphological patterns of restenosis after sirolimus-eluting stent (SES) implantation.From 121 patients with coronary angiography obtained >30 days SES implantation, (diameter stenosis >50%) was identified in 19 20 lesions (located at proximal 5-mm segment 30% or within 70%). Residual dissection procedure balloon trauma outside 83% edge lesions. Lesions were focal, discontinuity some evaluated by intravascular ultrasound.Sirolimus-eluting is frequently associated local stent. In-stent occurs as a localized lesion, commonly coverage. Local conditions instead intrinsic drug-resistance to sirolimus are likely play major role post-SES restenosis.