Impaired Microvascular Function in Obesity

• DOI: 10.1161/01.cir.0000129772.26647.6f
• Publication Date: 2004-05-11T01:04:21Z
• Authors: Renate T. de Jongh; Erik H. Serné; Richard G. IJzerman; Greetje de Vries; Coen D.A. Stehouwer
• Keywords: Hyperinsulinemia; Sodium nitroprusside; Endothelial Dysfunction; Basal (medicine)

Background— Obesity is associated with an increased risk of developing microangiopathy, hypertension, and insulin resistance. We hypothesized that obesity a primary cause microvascular dysfunction, which may contribute to the development these obesity-related disorders. Methods Results— examined function in 16 lean (body mass index <24 kg/m 2 ) 12 obese >30 healthy women (mean age, 38.9±6.7 years) basal state during physiological systemic hyperinsulinemia. determined skin capillary recruitment after arterial occlusion capillaroscopy endothelium–(in)dependent vasodilation by iontophoresis acetylcholine sodium nitroprusside. Obese women, compared had higher systolic blood pressure ( P <0.05), impaired sensitivity <0.01), <0.05) hyperinsulinemia acetylcholine-mediated <0.01). Sodium nitroprusside–mediated was similar women. Capillary were positively correlated r =0.58, <0.01 =0.55, <0.01, respectively) negatively =−0.64, <0.001 =−0.42, <0.05, both Conclusions— characterized and, dysfunction decreased sensitivity. These findings are consistent contribution