Extracorporeal Cardiac Shock Wave Therapy Markedly Ameliorates Ischemia-Induced Myocardial Dysfunction in Pigs in Vivo

• DOI: 10.1161/01.cir.0000148849.51177.97
• Publication Date: 2004-11-03T02:58:43Z
• Authors: Takahiro Nishida; Hiroaki Shimokawa; Keiji Oi; Hideki Tatewaki; Toyokazu Uwatoku; Kohtaro Abe; Yasuharu Matsumoto; Noriyoshi Kajihara; Masataka Eto; Takehisa Matsuda; Hisataka Yasui; Akira Takeshita; Kenji Sunagawa
• Keywords: Ischemic Cardiomyopathy

Background— Prognosis of ischemic cardiomyopathy still remains poor because the lack effective treatments. To develop a noninvasive therapy for disorder, we examined in vitro and vivo effects extracorporeal shock wave (SW) that could enhance angiogenesis. Methods Results— SW treatment applied to cultured human umbilical vein endothelial cells significantly upregulated mRNA expression vascular growth factor its receptor Flt-1 vitro. A porcine model chronic myocardial ischemia was made by placing an ameroid constrictor at proximal segment left circumflex coronary artery, which gradually induced total occlusion artery with sustained dysfunction but without infarction 4 weeks. Thereafter, region (200 shots/spot 9 spots 0.09 mJ/mm 2 ) performed (n=8), complete recovery ventricular ejection fraction (51±2% 62±2%), wall thickening (13±3% 30±3%), regional blood flow (1.0±0.2 1.4±0.3 mL · min −1 g weeks (all P <0.01). By contrast, animals did not receive (n=8) had (left fraction, 48±3% 48±1%; 13±2% 9±2%) (1.0±0.3 0.6±0.1 ). Neither arrhythmias nor other complications were observed during or after treatment. myocardium vivo. Conclusions— These results suggest cardiac is therapeutic strategy heart disease.