Short-Term Treatment With Atorvastatin Reduces Platelet CD40 Ligand and Thrombin Generation in Hypercholesterolemic Patients

• DOI: 10.1161/01.cir.0000153810.81187.7d
• Publication Date: 2005-02-01T14:52:43Z
• Authors: Valerio Sanguigni; Pasquale Pignatelli; Luisa Lenti; Domenico Ferro; Alfonso Bellia; Roberto Carnevale; Manfredi Tesauro; Roberto Sorge; Renato Lauro; Francesco Violi
• Keywords: Male; Multifactorial Inheritance; Platelet-derived factor; Coronary Disease; Hypercholesterolemia; Platelet-derived factors; Platelets; Statins; Thrombin; Monocyte; Pyrrole; blood level; Monocytes; low density lipoprotein cholesterol; 0302 clinical medicine; Peptide Fragment; Adenosine Diphosphate; Biological Markers; Blood Coagulation; Blood Platelets; CD40 Ligand; Collagen; Coronary Disease; Female; Fibrinolytic Agents; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Monocytes; Multifactorial Inheritance; Peptide Fragments; Prothrombin; Pyrroles; Solubility; Thrombin; Thromboplastin; Treatment Outcome; Atorvastatin; anticoagulation; clinical article; Fibrinolytic Agent; adult; Platelet; drug effect; article; Thrombin; thrombocyte antigen; atorvastatin; Middle Aged; 3. Good health; Heptanoic Acid; Adenosine Diphosphate; aged; female; Treatment Outcome; priority journal; Female; Prothrombin; Collagen; CD40 ligand; Human; Blood Platelets; in vitro study; hypercholesterolemia; platelet-derived factors; platelets; statins; thrombin; CD40 Ligand; Hypercholesterolemia; 610; atorvastatin; CD40 ligand; low density lipoprotein cholesterol; thrombocyte antigen; adult; aged; anticoagulation; antigen expression; article; blood clotting; blood level; clinical article; concentration response; controlled study; drug effect; female; human; human cell; hypercholesterolemia; in vitro study; male; Mediterranean diet; priority journal; short course therapy; upregulation; Adenosine Diphosphate; Biological Markers; Blood Coagulation; Blood Platelets; CD40 Ligand; Collagen; Coronary Disease; Female; Fibrinolytic Agents; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Monocytes; Multifactorial Inheritance; Peptide Fragments; Prothrombin; Pyrroles; Solubility; Thrombin; Thromboplastin; Treatment Outcome; blood clotting; Thromboplastin; 03 medical and health sciences; male; short course therapy; Fibrinolytic Agents; Mediterranean diet; Humans; controlled study; human; Blood Coagulation; human cell; Settore MED/09 - MEDICINA INTERNA; Statin; Peptide Fragments; Solubility; concentration response; Heptanoic Acids; Biological Marker; Blood Platelet; antigen expression; Hydroxymethylglutaryl-CoA Reductase Inhibitor; Hydroxymethylglutaryl-CoA Reductase Inhibitors; upregulation; Biomarkers

Soluble CD40L (sCD40L), a substance that maximally reflects in vivo platelet activation, is increased patients with hypercholesterolemia. We investigated the relation between sCD40L and CD4OL hypercholesterolemic before after short-term treatment atorvastatin.Collagen-induced plasma levels of prothrombin fragment F1+2, marker thrombin generation, were 30 20 healthy subjects. Hypercholesterolemic then randomized to either diet (n=15; group A) or atorvastatin 10 mg/d (group B); aforementioned variables measured at baseline 3 days treatment. Compared referents, showed higher values (P<0.005), F1+2 (P<0.003). Platelet was significantly correlated (P<0.001), latter (P<0.001). The intervention trial no changes A but significant decrease (P<0.01), (P<0.002), (P<0.03) B. In vitro studies demonstrated cholesterol enhanced CD40L-mediated clotting activation by human monocytes; also, dose-dependently inhibited expression CD40L-stimulated monocytes.This study shows that, hypercholesterolemia, overexpression may account for F1+2. Atorvastatin exerts direct antithrombotic effect via inhibition independently its cholesterol-lowering effect.