Alcohol Consumption Raises HDL Cholesterol Levels by Increasing the Transport Rate of Apolipoproteins A-I and A-II

• DOI: 10.1161/01.cir.102.19.2347
• Publication Date: 2012-06-12T00:42:29Z
• Authors: Elizabeth R. De O...; David Foster; Monnie McGee Harper; Cynthia E. Seidman; Jonathan D. Smith; Jan L. Breslow; Eliot A. Brinton
• Keywords: Consumption

Moderate alcohol intake is associated with lower atherosclerosis risk, presumably due to increased HDL cholesterol (HDL-C) concentrations; however, the metabolic mechanisms of this increase are poorly understood.We tested hypothesis that ethanol increases HDL-C by raising transport rates (TRs) major apolipoproteins apoA-I and -II. We measured turnover these in vivo paired studies without consumption 14 subjects. The fractional catabolic rate (FCR) TR radiolabeled -II were determined last 2 weeks a 4-week Western-type diet, (control) or isocaloric exchange for carbohydrates. Alcohol was given as vodka fixed amounts ranging from 0.20 0.81 g. kg(-1). d(-1) (mean+/-SD 0.45+/-0.19) reflect usual daily each subject. concentrations 18% compared control (Wilcoxon matched-pairs test, P=0.002). 10% (P=0.048) apoA-II 17% (P=0.005) higher TRs, respectively, whereas FCR both did not change. amount consumed correlated degree (Pearson's r=0.66, P=0.01) (r=0.57, P=0.03). also (r=0.61, P=0.02).Alcohol dose-dependent fashion, possibly caused an