Diastolic Fractional Flow Reserve to Assess the Functional Severity of Moderate Coronary Artery Stenoses

• DOI: 10.1161/01.cir.102.19.2365
• Publication Date: 2012-06-12T00:42:29Z
• Authors: Masayuki Abe; Hirofumi Tomiyama; Hideo Yoshida; Nobutaka Doba
• Keywords: Fractional Flow Reserve; Coronary flow reserve; Aortic pressure

Coronary blood flow occurs mainly during the diastolic phase of each cardiac cycle and is dependent on driving pressure, especially in left anterior descending coronary artery (LAD). We hypothesized that calculation ratio pressure a stenotic LAD to its normal value, namely FFR (d-FFR), might provide precise insight into mechanism for assessment functional severity stenosis. compared d-FFR with FFR, reserve (CFR), exercise myocardial thallium scintigraphy an lesion intermediate severity.The study population consisted 46 consecutive patients moderate stenosis whom simultaneous measurements aortic ventricular distal were obtained. velocity was successfully measured Doppler guidewire 37 patients. Values d-FFR, CFR noninvasive test-positive group significantly lower than those negative group. With cutoff values 0.75, 0.76, 2.0 CFR, sensitivities 83.3%, 95.8%, 88.2% specificities 100%, 95.0%, respectively.The close similarity sensitivity specificity around almost identical (0.75 versus 0.76), confirms physiological validity as clinical standard. In practice, remains index choice stenoses.