Factors Influencing Infarct Size Following Experimental Coronary Artery Occlusions

• DOI: 10.1161/01.cir.43.1.67
• Publication Date: 2012-06-11T23:56:43Z
• Authors: PETER R. MAROKO; JOHN K. KJEKSHUS; BURTON E. SOBEL; TAN WATANABE; JAMES W. COVELL; JOHN ROSS; EUGENE BRAUNWALD
• Keywords: Coronary occlusion; Creatine kinase

The purpose of this study was the determination whether hemodynamic and pharmacologic factors influence extent severity myocardial necrosis produced by coronary occlusion. In 48 dogs, 10 to 14 epicardial leads were recorded on anterior surface left ventricle in distribution vicinity site occlusion a branch descending artery. average S-T segment elevation for each animal determined at 5-min intervals after This used as an index presence ischemic injury. number sites showing provided additional measure size injured area. Occlusion alone raised from 0.22 ± 0.04 3.32 0.37 mv (SEM). Isoproterenol, ouabain, glucagon, bretylium, tachycardia given prior repeated increased injury, while propranolol decreased it. Elevation arterial pressure with methoxamine reduced occlusion-induced elevation, lowering mean hemorrhage had opposite effect. 19 experiments, propranolol, isoproterenol, alterations similar when these interventions applied long 3 hr ligation. third group creatine phosphokinase (CPK) activity 24 same which electrocardiograms taken. Depression CPK portions artery ligation correlated well 15 min Moreover, isoproterenol area depression activity. We conclude that status neurohumoral background time up thereafter can alter injury necrosis.