Reduction of enzyme levels by propranolol after acute myocardial infarction.

• DOI: 10.1161/01.cir.57.6.1091
• Publication Date: 2012-06-11T23:57:40Z
• Authors: T Peter; R M Norris; E D Clarke; M K Heng; B N Singh; B Williams; D R Howell; P K Ambler
• Keywords: Creatine kinase

The effect of propranolol (0.1 mg/kg intravenously followed by 320 mg given over 27 hour orally) on serum levels creatine kinase enzyme was studied in a randomized trial involving 95 patients seen within 12 hours onset symptoms uncomplicated myocardial infarction. In 15 who were treated with 4 onset, and eventually developed pathological Q waves, peak measured 27% (P less than 0.0125) lower 19 control also the but had no specific treatment. Total calculated appearance (reduced 25%, P 0.05) as rate (33%, 0.005). No significant difference found for compared entering more after chest pain. This evidence suggests that may reduce size infarctions if it is onset.