Influence of inflation pressure and balloon size on the development of intimal hyperplasia after balloon angioplasty. A study in the atherosclerotic rabbit.

• DOI: 10.1161/01.cir.80.4.1029
• Publication Date: 2011-06-17T20:29:13Z
• Authors: I J Sarembock; P J LaVeau; S L Sigal; I Timms; J Sussman; C Haudenschild; M D Ezekowitz
• Keywords: Balloon catheter

To evaluate the effect of balloon size and inflation pressure on acute subsequent outcome following angioplasty (BA), 70 New Zealand White rabbits with bilateral femoral atherosclerosis were assigned to four groups: group 1, oversized balloon, low (n = 35 vessels; size, 3.0 mm/inflation pressure, 5 atm); 2, high 36; mm/10 3, appropriate 17; 2.5 mm/5 4, 19; atm). Angiograms obtained before, 10 minutes after, 28 days after BA read by two blinded observers using electronic calipers. The in vivo balloon-to-vessel ratio was measured for each group. There eight non-BA controls. Rabbits sacrificed either immediately 34) or at 36), vessels perfused histologic morphometric analysis. latter performed only. Absolute angiographic diameters increased all groups (p less than 0.01). Acute success, defined as greater 20% increase luminal diameter, higher (group 32/36 [89%] 16/19 [84%] vs. 23/35 [66%] 9/17 [53%]; p 0.05). A 3.0-mm resulted significant oversizing irrespective (balloon-to-vessel ratio, 1.5 +/- 0.1 1.1 2.5-mm balloon). Vessels exposed had a significantly incidence mural thrombus, dissection 0.01), medial necrosis versus At days, rates restenosis (defined 50% loss initial gain) 14/20 (70%), 11/16 (69%), 5/10 (50%), (50%) 1 through 4 NS; trend favor an degree intimal hyperplasia analysis groups, being most marked 2 (oversized 1.7 0.9 0.5 0.2 mm controls, 0.001). We reached conclusions. First, protocols diameter highest success rate subjected dilatation.(ABSTRACT TRUNCATED AT 400 WORDS)