Effects of nifedipine on left ventricular diastolic function in patients with asymptomatic or minimally symptomatic hypertrophic cardiomyopathy.

• DOI: 10.1161/01.cir.81.2.593
• Publication Date: 2011-06-17T20:29:13Z
• Authors: T Yamakado; H Okano; S Higashiyama; M Hamada; T Nakano; H Takezawa
• Keywords: Afterload; Ventricular pressure; Isovolumic relaxation time

We investigated the effects of nifedipine on left ventricular diastolic function in 17 asymptomatic or minimally symptomatic patients with hypertrophic cardiomyopathy by simultaneously measuring pressure and volume a catheter-tipped manometer biplane cineangiography. Studies were performed before 20 minutes after sublingual administration (20 mg). Heart rates held constant (79 +/- 12 beats/min, mean SD) right atrial pacing. Left volumes instantaneous derived from frame-by-frame (20-msec) analyses angiograms. peak systolic (from 122 21 to 108 13 mm Hg, p less than 0.01 vs. control) aortic 96 15 87 11 0.01) decreased significantly nifedipine. With afterload reduction, ejection fraction 0.69 0.12 0.74 0.08, cardiac output 6.4 2.0 7.2 2.2 l/mm, 0.05) increased significantly. However, there was slight but significant increase end-diastolic 8 18 0.05). Nifedipine did not improve relaxation as assessed time constants isovolumic decay (t1/2, 39.8 6.6 39.4 7.7 msec, NS; t1/e, 53.8 9.0 54.4 10.7 NS).(ABSTRACT TRUNCATED AT 250 WORDS)