Physiological early diastolic intraventricular pressure gradient is lost during acute myocardial ischemia.

• DOI: 10.1161/01.cir.81.5.1688
• Publication Date: 2011-06-17T20:29:13Z
• Authors: M Courtois; S J Kovács; P A Ludbrook
• Keywords: Ventricular pressure; Systole; Pressure gradient

A consistent pattern of intraventricular regional pressure gradients exists under physiological conditions during the rapid filling phase diastole in normal dog left ventricle. We hypothesized that this gradient is caused, part, by early diastolic recoil ventricular walls conjunction with release elastic potential energy stored systole, generating suction and thus contributing to filling. If so, any condition interferes systolic function might be expected modify gradients. Accordingly, present study was designed determine whether acutely induced mechanical dysfunction accompanied changes Acute myocardial ischemia balloon occlusion anterior descending coronary artery (LAD) nine anesthetized closed-chest dogs. The maximum (MIVP) measured between mid-left ventricle apex a dual-sensor micromanometer (3-cm spacing sensors) before 20 minutes after LAD occlusion. Ejection fraction (EF) number dyskinetic chords (DChords) were from contrast ventriculograms. Twenty occlusion, dogs evidenced significant EF (56 +/- 10% 37 8%), DChords (0 0 17 16 chords), minimum (-1.7 0.5 0.0 1.5 mm Hg), end-diastolic (4.2 1.2 5.9 2.2 heart rate (90 103 18 beats/min).(ABSTRACT TRUNCATED AT 250 WORDS)