Probucol decreases neointimal formation in a swine model of coronary artery balloon injury. A possible role for antioxidants in restenosis.

• DOI: 10.1161/01.cir.88.2.628
• Publication Date: 2012-06-12T00:01:09Z
• Authors: J E Schneider; B C Berk; M B Gravanis; E C Santoian; G D Cipolla; N Tarazona; B Lassegue; S B King
• Keywords: Probucol; Lumen (anatomy); Neointima; Coronary arteries

Restenosis after percutaneous transluminal coronary angioplasty is the major limitation of long-term success this procedure. The process restenosis similar to an accelerated form atherosclerosis. Thus, therapeutic interventions that limit progression and initiation atherosclerosis may be beneficial in treatment restenosis. One such intervention antioxidant drug probucol, which has demonstrated benefit animal models atherosclerosis.Twenty-six female domestic swine were divided into three study groups (control, n = 9; low-dose high-dose 8) before oversized balloon injury left anterior descending circumflex arteries. Probucol (1 g/d, group; 2 group) was administered days continued until killed weeks injury. Morphometric analysis injured arteries included intimal area (square millimeters), maximal thickness (millimeters), residual lumen (ratio luminal plus area). Treatment with probucol significantly reduced neointimal formation compared control animals (decreases 36% area, P .007; 20% thickness, NS; increase 15% lumen, .02).The finding reduces a model This suggests active oxygen species play role