Intracoronary Radiation Before Stent Implantation Inhibits Neointima Formation in Stented Porcine Coronary Arteries

• DOI: 10.1161/01.cir.92.6.1383
• Publication Date: 2012-06-12T00:34:42Z
• Authors: Ron Waksman; Keith A. Robinson; Ian R. Crocker; Michael B. Gravanis; Spencer J. Palmer; Chris Wang; Gustavo D. Cipolla; Spencer B. King
• Keywords: Neointima; Coronary arteries; Circumflex; Coronary stent; Lumen (anatomy)

Stent implantation has been shown to reduce restenosis by establishing a larger lumen but not reducing neointima formation. We have previously that ionizing radiation reduced formation after balloon injury in swine model of restenosis. The purpose this study was determine whether endovascular irradiation the coronary artery before stent would affect formation.Nine normolipemic pigs underwent angiography, and segments left anterior descending circumflex arteries were chosen as targets for stenting. A high-activity 192Ir source used deliver 14 Gy random assignment one vessels. After this, 3.5-mm tantalum stents implanted both arteries. Three additional treated with 90Sr/Y (a pure beta-emitter) delivering five vessels stented immediately irradiation. Stent-to-artery ratio similar radiated control Animals received aspirin 325 mg daily killed at 28 days. intimal area significantly irradiated compared only (1.98 mm2 2.53 versus 3.82 arteries, P < .005).Endovascular stenting reduces may further rate implantation.