Increased Levels of Soluble P-Selectin in Hypercholesterolemic Patients

• DOI: 10.1161/01.cir.97.10.953
• Publication Date: 2012-06-12T00:41:02Z
• Authors: Giovanni Davı̀; Mario Romano; Andrea Mezzetti; Antonio Procopio; Stefano Iacobelli; Teresa Antidormi; Tonino Bucciarelli; Paola Alessandrini; Franco Cuccurullo; Gabriele Bittolo Bon
• Keywords: Endothelial Dysfunction; Pathogenesis; P-selectin; Endothelial Activation; Pathophysiology

Background —Hypercholesterolemia is considered a major risk factor for the development of atherosclerosis. Enhanced lipid peroxidation and persistent platelet activation can be observed in vivo hypercholesterolemic patients may have pathophysiological implications occurrence cardiovascular events. P-selectin play an important role pathogenesis multicellular events, including We studied impact hypercholesterolemia oxidative stress on plasma levels P-selectin. Methods Results —Plasma were measured by means enzyme immunoassay 20 with no clinical evidence disease sex- age-matched normocholesterolemic subjects. Hypercholesterolemic had higher compared that control subjects (98±61 versus 56±14 ng/mL; P =.001). They also displayed increased von Willebrand Factor (vWF) (176±22 119±12%; =.0001). A direct correlation was between LDL cholesterol (ρ=.453). Administration vitamin E (600 mg/d 2 weeks) to significantly reduced (40%), inverse (ρ=−.446). Conclusions associated elevated plasmatic Altered processes leading endothelial dysfunction contribute soluble levels. proposed as marker patients.