Interlesion Dependence of the Risk for Restenosis in Patients With Coronary Stent Placement in Multiple Lesions

• DOI: 10.1161/01.cir.97.24.2396
• Publication Date: 2012-06-12T00:41:02Z
• Authors: Adnan Kastrati; Albert Schömig; Shpend Elezi; Helmut Schühlen; Manfred Wilhelm; Josef Dirschinger
• Keywords: Male; Coronary Disease; Middle Aged; Coronary Angiography; 3. Good health; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Recurrence; Risk Factors; Odds Ratio; Humans; Female; Stents; Vascular Patency; Aged; Follow-Up Studies

Little is known about the behavior with regard to restenosis of multiple lesions within same patient treated intracoronary stenting. Our objective was test hypothesis that there an intrapatient dependence between lesions.Quantitative analysis carried out on angiograms obtained before, immediately after, and at 6 months after coronary stent placement in 1734 1244 patients. We used a specialized logistic regression not only accounts for intraclass correlation but also quantifies it form odds ratio (OR) as change risk lesion develop if another companion had restenosis. The model based 23 patient- lesion-related variables binary (diameter stenosis > or =50%) end point. overall rate 27.5%: 24.4% single-lesion, 28.6% double-lesion, 33.8% =3-lesion interventions. After adjustment influence significant factors (hypercholesterolemia, systemic arterial hypertension, diabetes mellitus, previous PTCA, ostial lesion, location left anterior descending artery, number stents placed, vessel size, severity, balloon-to-vessel ratio, final result), found correlation, OR 2.5 (1.8 3.6). This means patients multilesion interventions, times higher has restenosis, independently presence absence analyzed (eg, diabetes).This study demonstrates who undergo intervention. likelihood when developed Other, yet unidentified may be source this