Role of sympathetic activity in blood pressure reduction with low calorie regimen.

• DOI: 10.1161/01.hyp.17.6.965
• Publication Date: 2012-06-12T00:24:03Z
• Authors: T Kushiro; F Kobayashi; H Osada; H Tomiyama; K Satoh; Y Otsuka; H Kurumatani; N Kajiwara
• Keywords: Calorie; Phenylephrine

To investigate the effects of a low calorie regimen on sympathetic function and its relation to blood pressure response, 22 untreated obese essential hypertensive patients (50 +/- 2 years, body mass index 29 1 kg/m2) were hospitalized diet was prescribed 2,000 kcal/day for 5 days (control period) followed by 800 21 without changing salt intake (8-10 g/day). The dose intravenous phenylephrine infusion needed elevate systolic 20 mm Hg (CD20) 24-hour urinary excretion norepinephrine (UNE) measured. During period, normalized in 14 (responder group, 124 3/79 4 Hg) eight remained (poor responder 158 6/103 3 Hg). At control similar, but group had higher UNE (134 15 micrograms/day) CD20 (127 11 micrograms) than poor (89 6 micrograms/day 79 13 micrograms, respectively). both (87 (74 10 decreased group; no change seen group. Changes correlated (r = 0.6, p less 0.05). In conclusion, suppression activity plays role reduction during moderate caloric restriction.