Impaired Endothelium-Dependent Vasodilation of Large Epicardial and Resistance Coronary Arteries in Patients With Essential Hypertension

• DOI: 10.1161/01.hyp.25.2.201
• Publication Date: 2012-06-12T00:24:03Z
• Authors: Kensuke Egashira; Satoshi Suzuki; Yoshitaka Hirooka; Hisashi Kai; Masaru Sugimachi; Tsutomu Imaizumi; Akira Takeshita
• Keywords: Coronary arteries; Coronary circulation; Coronary vasodilator

Abstract Hypertensive patients have impaired endothelium-dependent coronary vasodilation evoked with acetylcholine. The aim of this study was to examine whether the dilation arteries is related a specific abnormality muscarinic receptor that mediates effects Responses large epicardial and resistance were assessed in seven hypertensive (mean arterial pressure, 106±14 mm Hg) control subjects (83±6 Hg, P <.01) during cardiac catheterization. To assess endothelial function, we infused acetylcholine substance (endothelium-dependent agents act on different receptors) papaverine nitrate (direct vascular smooth muscle dilators) into left anterior descending artery determined diameter by arteriography blood flow an intracoronary Doppler catheter technique. In subjects, 3 μg/min increased ( <.05) 30 decreased diameter, patients, 1, 3, 10, dose-dependent manner. Substance at ng/min caused comparable increases both groups. Increases significantly blunted compared subjects. No significant differences noted between groups responses nitrate. Vasodilation impaired, but response preserved indicating diminished may be receptor. Blunted suggest dysfunction condition more generalized not confined