l-Arginine Prevents Corticotropin-Induced Increases in Blood Pressure in the Rat

• DOI: 10.1161/01.hyp.27.2.184
• Publication Date: 2012-06-12T00:53:46Z
• Authors: Steven W. Turner; Cheng Wen; Ming Li; Judith A. Whitworth
• Keywords: Corticosterone

Abstract In this study we examined whether l -arginine treatment could prevent corticotropin (ACTH)–induced increases in blood pressure the Sprague-Dawley rat. Sixty rats were randomly divided into six groups (n=10): sham injection, ACTH injection (0.5 mg/kg per day doses), (0.6%) food plus treatment, d and ACTH. Systolic pressure, water intake, urine volume, body weight, plasma urinary electrolytes, serum corticosterone concentrations measured. increased systolic (from 127±2 to 165±6 mm Hg, P <.001), volume decreased weight. -Arginine reduced ACTH-induced rises (130±3 <.001) but had no effect on sham-treated rats. did not affect rats, -arginine+ACTH–treated was similar that of ACTH-treated (424±43 versus 238±25 ng/mL, <.01), effect. However, both drugs (1071±117 739±95 695±72 ng/mL for - -arginine, respectively; <.05). As prevented effects preventing hypertension simply a consequence secretion.