Angiotensin II Signaling in Vascular Smooth Muscle

• DOI: 10.1161/01.hyp.29.1.366
• Publication Date: 2012-06-12T00:53:46Z
• Authors: Kathy K. Griendling; Masuko Ushio-Fukai; Bernard Lassègue; R. Wayne Alexander
• Keywords: 0301 basic medicine; 03 medical and health sciences; 3. Good health

Angiotensin II is a multifunctional hormone that affects both contraction and growth of vascular smooth muscle cells through complex series intracellular signaling events initiated by the interaction angiotensin with AT 1 receptor. The cellular response to multiphasic, involving stimulation within seconds phospholipase C Ca 2+ mobilization; activation minutes D, A 2 , protein kinase C, MAP kinase; after period hours gene transcription NADH/NADPH oxidase activity. also activates numerous tyrosine kinases. In this respect, it shares some aspects factor cytokine receptors, including C-γ, src, ras; association shc grb2; Jak/STAT pathway. responsible for unique may involve receptor movement creation domain. Elucidation these pathways important our understanding function as final effector renin-angiotensin system.