Dietary Salt Intake Modulates Angiotensin II Type 1 Receptor Gene Expression

• DOI: 10.1161/01.hyp.29.4.923
• Publication Date: 2012-06-12T00:53:46Z
• Authors: Charlotte Schmid; Hayo Castrop; Jürgen Reitbauer; Roberto Della Bruna; Armin Kurtz
• Keywords: Receptor expression

Abstract This study aimed to characterize the influence of dietary salt intake on gene expression angiotensin II type 1 (AT ) receptor subtypes in different organs. Male Sprague-Dawley rats were fed low (0.2 mg/g), normal (6 or high (40 mg/g) diets for 5, 10, and 20 days. mRNA levels two AT determined adrenal gland, kidney, liver, lung. In all organs examined, with exception glands, diet led a transient decrease abundance 1A but not 1B mRNA, which reached their nadirs between days 5 10 feeding. is predominant, increase this gene, maximum around day High exerted no significant these These findings indicate that rate intake, particular, reduction significantly influences an organ-, time-, subtype-dependent fashion. It appears are differentially influenced by increases decreases situation. differential response may be relevant organism able adapt oral intake.