Renal Changes Induced by Nitric Oxide and Prostaglandin Synthesis Reduction

• DOI: 10.1161/01.hyp.31.2.657
• Publication Date: 2012-06-12T00:53:46Z
• Authors: Maria T. Llinás; Juan D. González; Francisca Rodríguez; Eduardo Nava; Stefano Taddei; F. Javier Salazar
• Keywords: Renal circulation

Abstract —The benefits of the simultaneous administration low doses a calcium antagonist and converting enzyme inhibitor in treatment hypertension renal vasoconstriction are well established. The objective this study was to evaluate whether converting-enzyme have beneficial effects treating alterations induced by acute cyclooxygenase when nitric oxide synthesis is reduced. These were examined anesthetized dogs before during an sodium load. It found that intrarenal infusion meclofenamate (5 μg · kg −1 min ), simultaneously with dose N G -nitro- l -arginine methyl ester (1 produced 40% decrease blood flow glomerular filtration rate reduction excretory response In second group dogs, verapamil (0.5 ) effective blocking prostaglandin inhibition on excretion but did not modify flow. An trandolapril (0.3 third reducing hemodynamic preventing antinatriuretic effect observed first group. Finally, fourth group, all changes results suggest combination has additive antinatriuresis inhibitor,