Left ventricular mass reduction during salt depletion in arterial hypertension.

• DOI: 10.1161/01.hyp.6.5.755
• Publication Date: 2012-06-12T00:22:33Z
• Authors: L A Ferrara; G de Simone; F Pasanisi; M Mancini; M Mancini
• Keywords: Chlorthalidone; Crossover study; Essential hypertension

Long-term therapy with antihypertensive agents that reduce sympathetic nervous system activity has been demonstrated by echocardiographic measurements to reverse left ventricular hypertrophy. This investigation evaluated the effects of salt depletion obtained both chlorthalidone (25 mg/day) and severe restriction intake (about 1016 mg Na+/day) on mass (LVM) in as short a time 12 weeks. Before study, patients had off medication balanced diet without for at least 2 weeks; they were then randomly allocated either diuretic or low-salt regimen 6 weeks finally alternative treatment according crossover model. Blood pressure, body weight, myocardial mass, noninvasive function (LVF) determined baseline end periods treatment. Results two-way analysis variance randomized blocks. Systolic diastolic blood pressure LVM significantly similarly reduced restriction. A significant correlation was between LVM, expressed cross-sectional area, systolic pressure. No impairment LVF could be detected over period.