Angiogenic Role of LYVE-1–Positive Macrophages in Adipose Tissue

• DOI: 10.1161/01.res.0000259564.92792.93
• Publication Date: 2007-02-03T06:46:56Z
• Authors: Chung-Hyun Cho; Young Jun Koh; Jinah Han; Hoon-Ki Sung; Hyuek Jong Lee; Tohru Morisada; Reto A. Schwendener; Rolf A. Brekken; Guson Kang; Yuichi Oike; Tae-Saeng Choi; Toshio Suda; Ook-Joon Yoo; Gou Young Koh
• Keywords: Adipose tissue macrophages

Here we report the discovery of a characteristic dense vascular network (DVN) in tip portion epididymal adipose tissue adult mice. The DVN is formed by angiogenesis rather than vasculogenesis, and has functional blood circulation. This its subsequent branching may provide new route for adipogenesis. recruitment, infiltration, accumulation bone marrow-derived LYVE-1 + macrophages region are crucial formation DVN. Matrix metalloproteinases (MMPs) VEGF-VEGFR2 system responsible not only DVN, but also recruitment infiltration into region. SDF-1, MCP-1-CCR2 system, critical factor ongoing retention this area. We demonstrate that highly hypoxic, thus provides microenvironment conducive to high expression enhanced activities VEGF, VEGFR2, MMPs, SDF-1 autocrine paracrine manners, create an ideal niche retention, angiogenic action macrophages. These findings shed light on complex interplay between macrophage angiogenesis, adipogenesis tissue, novel insight regulation alternative outgrowth tissue.