Bone Formation in Carotid Plaques

• DOI: 10.1161/01.str.0000013741.41309.67
• Publication Date: 2002-07-28T23:16:07Z
• Authors: Jennifer L. Hunt; Ronald Fairman; Marc E. Mitchell; Jeffrey P. Carpenter; Michael Golden; Tigran Khalapyan; Megan Wolfe; David Neschis; Ross Milner; Benjamin Scoll; Anita Cusack; Emile R. Mohler
• Keywords: Dystrophic calcification; Stroke

Background and Purpose — Bone formation dystrophic calcification are present in carotid endarterectomy plaques. The clinical significance of these findings is unknown. purpose this study was to determine whether bone extensive associated with stable plaques protective against ischemic vascular events. Methods Carotid were collected from 142 patients (94 men) stenosis. specimens evaluated for lamellar formation, calcifications, inflammatory infiltrates, neovascularization, histological type or grade plaque according a standard AHA grading system. Immunohistochemical staining performed identify endothelial cells neovascularization (factor VIII) lymphocytes. Clinical data, including history cerebrovascular cardiovascular events, recorded at the time surgery. Results Patients had fewer symptoms stroke transient attack ( P =0.042) than those without calcification. Stroke occurred less frequently large calcific granules =0.021). Of patients, 13% which directly correlated presence sheetlike calcifications =0.0001) inversely ulcerated lesions =0.048). also diabetes <0.01) coronary artery disease <0.01). 20 bone, 6 stoke =0.5). Conclusions results indicate that tends occur heavily calcified devoid ulceration hemorrhage. likely have symptomatic disease.