Favorable Outcome of Ischemic Stroke in Patients Pretreated with Statins

• DOI: 10.1161/01.str.0000125863.93921.3f
• Publication Date: 2004-04-13T00:43:56Z
• Authors: Joan Martí-Fàbr...; Meritxell Gomis; Adrià Arboix; Aitziber Aleu; Javier Pagonabarraga; Robert Belvís; Dolores Cocho; Jaume Roquer; Ana Rodríguez; María Dolores Ga...; Laura Molina-Porcel; Jordi Díaz-Manera; Josep-Lluis Marti...
• Keywords: Stroke; Univariate analysis

Background and Purpose— Statins may be beneficial for patients with acute ischemic stroke. We tested the hypothesis that pretreated statins at onset of stroke have less severe neurological effects a better outcome. Methods— prospectively included consecutive <24-hour duration. recorded demographic data, vascular risk factors, Oxfordshire Classification, National Institutes Health Stroke Scale (NIHSS) score, admission blood glucose body temperature, cause (Trial Org 10172 in Acute Treatment [TOAST] criteria), progression day 3, previous statin treatment, outcome 3 months. analyzed data using univariate methods logistic regression dependent variable good (modified Rankin [mRS] 0 to 1, Barthel Index [BI] 95 100). Results— 167 (mean age 70.7±12 years, 94 men). Thirty (18%) were when admitted. In group, median NIHSS score was not significantly lower reduced. Favorable outcomes months more frequent group (80% versus 61.3%, P =0.059 mRS; 76.7% 51.8%, =0.015 BI). Predictors favorable BI were: (OR: 0.72; CI: 0.65 0.80; <0.0001), 0.96; 0.92 0.99; =0.017), 5.55; 1.42 17.8; =0.012). Conclusions— provide benefits long-term functional administered before cerebral ischemia. However, randomized controlled trials will required evaluate validity our results.