Dementia After Stroke

• DOI: 10.1161/01.str.0000127810.92616.78
• Publication Date: 2004-05-04T00:49:25Z
• Authors: Cristina S. Ivan; Sudha Seshadri; Alexa Beiser; Rhoda Au; Carlos S. Kase; Margaret Kelly-Hayes; Philip A. Wolf
• Keywords: Stroke; Framingham Heart Study

Background and Purpose— Identification of risk factors for dementia after stroke is best performed in comparison with stroke-free controls, because older subjects at high also have a substantial the absence stroke. Previous case-control studies were hospital-based. We used nested design to prospectively evaluate these community-based Framingham Study cohort. Methods— compared 212 who free January 1982 sustained first this date, 1060 age- sex-matched, stroke- dementia-free controls. calculated 10-year risks (by Diagnostic Statistical Manual Mental Disorders , Volume IV criteria) developing cases controls estimated hazard ratios within subgroups defined by exposure various demographic (age, gender, education), stroke-related features (right or left hemisphere, type, second stroke), (hypertension, diabetes, atrial fibrillation, smoking) apolipoprotein E genotype. Results— Dementia developed 19.3% 11.0% Baseline doubled (hazard ratio [HR]: 2.0; 95% confidence interval [CI]: 1.5 3.1) adjustment age, sex, education, individual did not diminish (HR: 2.4; CI: 1.6 3.7). The HR was higher younger (age than 80 years [HR: 2.6; 4.5]), 3/3 homozygotes 3.4; 2.0 5.8), school graduates 3.9). Conclusion— Stroke increases subject’s as sex-matched Primary secondary prevention should significantly decrease all dementia.