Molecular Signatures of Vascular Injury Are Associated With Early Growth of Intracerebral Hemorrhage

• DOI: 10.1161/01.str.0000149615.51204.0b
• Publication Date: 2004-11-19T01:33:17Z
• Authors: Yolanda Silva; Rogelio Leira; Javier Tejada; José M. Lainez; José Castillo; Antoni Dávalos
• Keywords: Quartile

To investigate whether molecular markers of inflammation and endothelial injury are associated with early growth intracerebral hemorrhage (ICH).In a multicenter prospective study, we determined concentrations interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), matrix metalloproteinase-9 (MMP-9), cellular fibronectin (c-Fn) in blood samples obtained on admission from 183 patients primary hemispheric ICH <12 hours' duration. Patients had neurological evaluation computed tomography (CT) scan performed at baseline 48+/-6 hours. Early the was defined as volume increase >33% between 2 CT examinations for <20 mL >10% > or =20 mL. Clinical, radiological, biochemical predictive factors enlargement were analyzed by logistic regression analysis.Fifty-four (29.5%) showed relevant ICH. High leukocyte count fibrinogen levels, low platelet count, intraventricular bleeding bivariate analyses. Plasma IL-6 (median [quartiles]: 19.6 [13.6; 29.9] versus 15.9 [11.5; 19.8] pg/mL), TNF-alpha (13.5 [8.4; 30.5] 8.7 [4.7; 13.5] MMP-9 (153.3 [117.7; 204.7] 70.6 [47.8; 103.8] ng/mL), c-Fn (8.8 [6.2; 12.5] 2.8 [1.6; 4.2] microg/mL) significantly higher (all P<0.001). C-Fn levels >6 microg/mL (OR, 92; 95%CI, 22 to 381; P<0.0001) IL-6>24 pg/mL 16; 2.3 119; P=0.005) independently analysis.Molecular signatures vascular inflammatory acute phase subsequent hematoma.