Increased neuropeptide Y concentrations in cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage.

Male Time Factors Calcitonin Gene-Related Peptide Osmolar Concentration Intracranial Aneurysm Nerve Tissue Proteins Middle Aged Subarachnoid Hemorrhage 3. Good health Neuroendocrine Secretory Protein 7B2 Pituitary Hormones 03 medical and health sciences 0302 clinical medicine Humans Female Neuropeptide Y Atrial Natriuretic Factor Chromatography, High Pressure Liquid Aged
DOI: 10.1161/01.str.20.12.1680 Publication Date: 2011-06-17T20:08:03Z
ABSTRACT
We investigated the possible relation between neuropeptides and cerebral vasoconstriction in samples of ventricular or cisternal cerebrospinal fluid from 14 patients with subarachnoid hemorrhage. Neuropeptide Y, calcitonin gene-related peptide, atrial natriuretic peptide, and pituitary polypeptide 7B2 were present in the cerebrospinal fluid of these patients. Concentrations of calcitonin gene-related peptide and 7B2 were not significantly different from those in control subjects, but that of atrial natriuretic peptide was significantly lower. Although the mean concentration of neuropeptide Y was not significantly higher than control, consecutive determinations showed an increase 6-11 days after the onset of subarachnoid hemorrhage. An initially high 7B2 concentration decreased gradually, although half the patients showed a second increase greater than 10 days after the onset. Considering the well-recognized vasoconstrictive effect of neuropeptide Y, it is possible that this increase in its concentration in the cerebrospinal fluid plays a role in the pathogenesis of the cerebral vasospasm that is often seen after subarachnoid hemorrhage.
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