Glucose affects the severity of hypoxic-ischemic brain injury in newborn pigs.

• DOI: 10.1161/01.str.24.7.1055
• Publication Date: 2011-06-17T20:10:52Z
• Authors: M H LeBlanc; M Huang; V Vig; D Patel; E E Smith
• Keywords: Blood sugar; Ischemic injury

The administration of glucose has been shown to worsen brain injury in adult animals but no effect on the severity newborn rats. We wished see whether results rats could be extended another animal.In 44 0- 3-day-old piglets, hypoxic-ischemic central nervous system damage was induced by ligation both carotid arteries and reduction their blood pressure two-thirds normal for one-half hour. In last 15 minutes this half hour, oxygen concentration reduced 6%. piglets were randomized receive either 2 mL/kg 50% dextrose water followed per hour 2.5 hours beginning before ischemia or enough insulin reduce resting sugar approximately mmol/L.Neurological exam scores glucose-treated at 1 day after significantly worse than those insulin-treated group. Pathological examination poorer group (13.6 +/- 1.9 [mean SEM]) (24.7 1.4, P < .01).Increasing serum during piglet's worsens injury.