Central Benzodiazepine Receptor Distribution After Subcortical Hemorrhage Evaluated by Means of [ 123 I]Iomazenil and SPECT

• DOI: 10.1161/01.str.26.12.2267
• Publication Date: 2011-06-17T20:10:52Z
• Authors: Jun Hatazawa; Eku Shimosegawa; Takao Satoh; Iwao Kanno; Kazuo Uemura
• Keywords: Cerebral Cortex; Flumazenil; Male; Tomography, Emission-Computed, Single-Photon; Middle Aged; Receptors, GABA-A; Iodine Radioisotopes; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Cerebral Hemorrhage

[123I]Iomazenil is a single-photon emission computed tomography (SPECT) tracer that selectively binds to central benzodiazepine receptor in the neuron membrane. With this ligand, we studied distribution cortex remote from subcortical hematoma intracerebral hemorrhage patients.Four patients with unilateral putaminal and one patient right thalamic were (mean +/- 1 SD age, 50.0 8.8 years). The initial volume of ranged 4.3 31.0 mL SD, 17.5 12.3 mL). SPECT images obtained 3 hours after intravenous administration [123I]iomazenil (167 MBq/750 ng) analyzed. In three patients, perfusion was evaluated [123I]IMP. On images, radioactivity ratio ipsilateral contralateral cerebral (I/C ratio) or cerebellar hemisphere (C/I measured.The I/C for iomazenil significantly decreased compared unity temporal lobe (0.84 0.08, P < .01) parietal (0.87 0.10, .05), but C/I cerebellum (1.00 0.03) not. (0.83 0.04, normal subjects.Central receptor-[123I]iomazenil binding hematoma. This preliminary result may facilitate further study potential damage cortical neurons