Nocturnal Blood Pressure and Silent Cerebrovascular Lesions in Elderly Japanese

• DOI: 10.1161/01.str.27.8.1319
• Publication Date: 2011-06-17T20:08:03Z
• Authors: Noriko Watanabe; Yutaka Imai; Kenichi Nagai; Ichiro Tsuji; Hiroshi Satoh; Mariko Sakuma; Hiromichi Sakuma; Junko Kato; Noriko Onodera-Ki...; Masaaki Yamada; Fumiaki Abe; Shigeru Hisamichi; Keishi Abe
• Keywords: Male; Blood Pressure; Cerebral Infarction; Middle Aged; Magnetic Resonance Imaging; Brain Ischemia; Circadian Rhythm; 3. Good health; Cohort Studies; Cerebrovascular Disorders; 03 medical and health sciences; Age Distribution; Cross-Sectional Studies; 0302 clinical medicine; Japan; Hypertension; Humans; Female; Aged

Background and Purpose We conducted a cross-sectional epidemiological survey using ambulatory blood pressure monitoring brain MRI in cohort from northern Japan to determine whether an inappropriately low nocturnal pressure, or excess fall might be responsible for silent cerebrovascular lesions the elderly. Methods Untreated subjects over 55 years under 64 of age (late middle age; 24 men 46 women, 60% eligible people) 65 75 (elderly; 29 52 91% participated study. evaluated relationship between amplitude (Daytime Average−Nighttime Average) rate ([Daytime Average]/Daytime incidence on (number lacunar infarctions extent periventricular hyperintensity). Results The elderly women with one two was significantly higher than that those without such infarctions. There significant positive correlation hyperintensity women. This observed but not men, late this seen men. Conclusions indicate excessive is associated ischemic lesions, at least Treatment hypertension should administered care regard pressure.