Postural Dysregulation in Systolic Blood Pressure Is Associated With Worsened Scoring on Neurobehavioral Function Tests and Leukoaraiosis in the Older Elderly Living in a Community

• DOI: 10.1161/01.str.28.11.2169
• Publication Date: 2011-06-17T20:08:03Z
• Authors: Kozo Matsubayashi; Kiyohito Okumiya; Tomoko Wada; Yasushi Osaki; Michiko Fujisawa; Yoshinori Doi; Toshio Ozawa
• Keywords: Supine position; Leukoaraiosis

Background and Purpose Postural hypotension, which occurs frequently in community-living, apparently healthy elderly adults, is usually asymptomatic. However, the relation between postural changes blood pressure quantitative higher cerebral function or silent brain lesions remains unclear. We examined association of exaggerated systolic with cognitive neurobehavioral functions on MRI community-dwelling older elderly. Methods The study population consisted 334 aged 75 years (mean age, 80 years). (SBP) were assessed using an autosphygmomanometer (BP-203 I). By difference mean two measurements SBP at standing supine position (dSBP=SBP upright−SBP position), we divided subjects into three groups: (1) 20 hypotension (d-SBP ≦−20 mm Hg), (2) 29 hypertension (dSBP ≧20 (3) 285 normotension (20<dSBP<20 Hg). defined former groups as dysregulation group. Scores four tests (Mini-Mental State Exam, Hasegawa Dementia Scale Revised, computer-assisted visuospatial performance score, Up Go Test) activities daily living compared among groups. Brain MRI, including number lacunes periventricular hyperintense lesions, 15 age- sex-matched control hypertension, 30 normotension. Results Twenty (6.0%) exhibited (8.7%) hypertension. significantly lower group (both groups) than more advanced hyperintensities Conclusions Asymptomatic individuals well those had poorer scores leukoaraiosis demonstrated without SBP.