Treatment of Intraventricular Hemorrhage With Urokinase

• DOI: 10.1161/01.str.31.4.841
• Publication Date: 2011-06-17T20:10:52Z
• Authors: Neal J. Naff; Juan R. Carhuapoma; Michael A. Williams; Anish Bhardwaj; John A. Ulatowski; Joshua Bederson; Ross Bullock; Erich Schmutzhard; Bettina Pfausler; Penelope M. Keyl; Stanley Tuhrim; Daniel F. Hanley
• Keywords: Glasgow Outcome Scale

Background and Purpose —Intraventricular hemorrhage (IVH) remains associated with high morbidity mortality. Therapy external ventricular drainage alone has not modified outcome in these patients. Methods —Twelve pilot IVH patients who required were prospectively treated intraventricular urokinase followed by the randomized, double-blinded allocation of 8 to either treatment or placebo. Observed 30-day mortality was compared predicted obtained use a previously validated method. Results —Twenty enrolled; admission Glasgow Coma Scale score 11 ≤8; 10 had pulse pressure <85 mm Hg. Mean±SD ICH volume 16 6.21±7.53 cm 3 (range 0 23.88 ), mean±SD hematoma 44.26±31.65 1.31 100.36 ). Four (20%) died within 30 days. Predicted for 20 68.42% 3% 100%). Probability observing ≤4 deaths among under expected is 0.000012. Conclusions may significantly improve survival On basis current evidence, double-blinded, placebo-controlled, multicenter study that uses thrombolysis treat received funding began January 1, 2000.