Abstract 2021: 18 F-Sodium Fluoride Positron Emission Tomography To Assess Thoracic Aortopathy In Bicuspid Aortic Valve Disease

• DOI: 10.1161/atvb.44.suppl_1.2021
• Publication Date: 2024-07-24T13:03:55Z
• Authors: Jennifer Nash; Samuel Debono; Krithika Loganath; Beth Whittington; Evangelos Tzolos; Maaz Syed; Tijana Mitic; Adriana Tavares; Mark Macaskill; Tim Clark; Scott Semple; Edwin Van Beek; Damini Dey; Piotr J Slomka; Rachael Forsythe; Michelle Williams; Marc Dweck; Niki Walker; David E Newby; Alexander J Fletcher
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Background: Bicuspid aortic valve is associated with thoracic aortopathy many patients suffering dissection below the diameter threshold for prophylactic replacement surgery. In aortopathy, wall media initially undergoes increasing microcalcification due to elastin fibre fragmentation but disease progression, degradation leads loss of microcalcification. 18 F-Sodium fluoride positron emission tomography (PET) a non-invasive method detecting arterial that has been successfully used in cardiovascular risk stratification. Aims: To determine if F-sodium imaging can identify and predict subsequent progression bicuspid disease. Methods: this prospective cohort study, 77 from clinical sites across Scotland healthy volunteers, underwent PET-computed (PET-CT) followed immediately by PET-magnetic resonance (PET-MRI). Maximum standardised uptake values (SUVmax) were determined ascending aorta. Aortic diameters measured axial CINE MRI sequences. Patients followed-up at 24 months further PET-MRI. Annualised change size index (mm/m 2 /year) annualised SUVmax stratified tertiles calculated. Results: had higher than control subjects, especially those dilatation. Baseline was expansion rate independent baseline (β=0.45, p=0.001). tertile 1 (loss over time) exhibited greater growth (0.60±0.50 mm/m stable (tertile 2, 0.26±0.36 or 3, 0.24±0.36 /year; p=0.01). Conclusion: activity increased valve. Loss more rapid represents promising new approach identification complications.