Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease

• DOI: 10.1161/atvbaha.108.165886
• Publication Date: 2008-04-17T01:37:19Z
• Authors: Michal L. Melamed; Paul Muntner; Erin D. Michos; Jaime Uribarri; Collin Weber; Jyotirmay Sharma; Paolo Raggi
• Keywords: Male; Peripheral Vascular Diseases; Middle Aged; Nutrition Surveys; United States; Phosphates; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Parathyroid Hormone; Predictive Value of Tests; Multivariate Analysis; Prevalence; Humans; Calcium; Female; Vitamin D; Biomarkers; Aged; Retrospective Studies

The purpose of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) levels and prevalence peripheral arterial disease (PAD) in general United States population.We analyzed data from 4839 participants National Health Nutrition Examination Survey 2001 2004 evaluate relationship 25(OH)D PAD (defined as an ankle-brachial index < 0.9). Across quartiles 25(OH)D, lowest highest, 8.1%, 5.4%, 4.9%, 3.7% (P trend 0.001). After multivariable adjustment for demographics, comorbidities, physical activity level, laboratory measures, ratio lowest, compared quartile (< 17.8 > or = 29.2 ng/mL, respectively) 1.80 (95% confidence interval: 1.19, 2.74). For each 10 ng/mL lower multivariable-adjusted 1.35 1.15, 1.59).Low serum are associated with a higher PAD. Several mechanisms have been invoked literature support potential antiatherosclerotic vitamin D. Prospective cohort mechanistic studies should be designed confirm association.