Lipoprotein(a) and Risk of Coronary, Cerebrovascular, and Peripheral Artery Disease

• DOI: 10.1161/atvbaha.112.255521
• Publication Date: 2012-10-13T01:30:54Z
• Authors: Deepti Gurdasani; Barbara Sjouke; Sotirios Tsimikas; G. Kees Hovingh; Robert N. Luben; Nicholas W. J. Wa...; Cristina Pomilla; Nicholas J. Wareham; Kay-Tee Khaw; S. Matthijs Boekh...; Manjinder S. Sandhu
• Keywords: Lipoprotein(a); Stroke

Although the association between circulating levels of lipoprotein(a) [Lp(a)] and risk coronary artery disease (CAD) stroke is well established, its role in peripheral arterial (PAD) remains unclear. Here, we examine Lp(a) PAD a large prospective cohort. To contextualize these findings, also examined CAD studied low-density lipoprotein as an effect modifier Lp(a)-associated cardiovascular risk.Lp(a) were measured apparently healthy participants European Prospective Investigation Cancer (EPIC)-Norfolk Cox regression was used to quantify PAD, stroke, outcomes. During 212 981 person-years at risk, total 2365 CAD, 284 ischemic 596 events occurred 18 720 participants. associated with outcomes but not (hazard ratio per 2.7-fold increase 1.37, 95% CI 1.25-1.50, 1.13, 1.04-1.22 0.91, 0.79-1.03, respectively). Low-density cholesterol did modify associations.Lp(a) future events. The modified by levels.