Plasma–Parathyroid Hormone Is Associated With Subclinical and Clinical Atherosclerotic Disease in 2 Community-Based Cohorts

• DOI: 10.1161/atvbaha.113.303062
• Publication Date: 2014-03-14T01:18:03Z
• Authors: Emil Hagström; Karl Michaëlsson; Håkan Melhus; Thomas Hansen; Håkan Ahlström; Lars Johansson; Erik Ingelsson; Johan Sundström; Lars Lind; Johan Ärnlöv
• Keywords: Subclinical infection

Cardiovascular risk factors have different impact on arterial territories. Diseases with elevated circulating parathyroid hormone (PTH) such as primary hyperparathyroidism and chronic renal failure been shown to be associated an increased of cardiovascular disease, predominantly heart or cerebrovascular diseases. However, data the associations between PTH peripheral atherosclerosis are limited.Two prospective, community-based studies were used. In 306 men women, who 70 years old, from Prospective investigation vasculature in Uppsala seniors (PIVUS) study, cross-sectional relations atherosclerotic burden assessed by whole-body magnetic resonance angiography investigated. 998 men, 71 longitudinal study adult (ULSAM) association concentration subsequent nonfatal disease (excluding coronary disease) was Adjusting for established vascular factors, (increase total score per SD increase: 0.04, 0.003-0.08; P=0.03) PIVUS study. During follow-up ULSAM (median 16.7 years), 89 diagnosed disease. Cox-regression analyses adjusting mineral metabolism, higher (hazard ratio 1 increase PTH: 1.55, 1.33-1.88; P<0.0001). Results similar when including fatal outcome.In 2 independent cohorts, degree clinically overt respectively. Our confirm extend previous supporting a role development