Residential Proximity to Major Roadways Is Associated With Increased Levels of AC133 + Circulating Angiogenic Cells

• DOI: 10.1161/atvbaha.115.305724
• Publication Date: 2015-08-21T02:39:36Z
• Authors: Natasha DeJarnett; Ray Yeager; Daniel J. Conklin; Jongmin Lee; Timothy E. O’Toole; James McCracken; Wes Abplanalp; Sanjay Srivastava; Daniel W. Riggs; Ihab Hamzeh; Stephen Wagner; Atul Chugh; Andrew DeFilippis; Tiffany Ciszewski; Brad Wyatt; Carrie Becher; Deirdre Higdon; Kenneth S. Ramos; David J. Tollerud; John A. Myers; Shesh N. Rai; Jasmit Shah; Nagma Zafar; Sathya S. Krishna...; Sumanth D. Prabhu; Aruni Bhatnagar
• Keywords: CD31

Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease risk. Yet, the nature of this association remains unclear, and its effect on individual risk factors has not been assessed. The objective study was determine whether roadways influences systemic inflammation levels circulating angiogenic cells.In cross-sectional study, factors, blood C-reactive protein, 15 antigenically defined cell populations were measured in participants (n=316) moderate-to-high Attributes surrounding locations assessed using geographic information systems. Associations between road indices analyzed generalized linear models. Close (<50 m) major lower income higher rates smoking but protein levels. After adjustment for potential confounders, cells peripheral significantly elevated people living close (CD31(+)/AC133(+), AC133(+), CD34(+)/AC133(+), CD34(+)/45(dim)/AC133(+) cells) positively segment distance CD34(+)/AC133(+) cells), traffic intensity (CD31(+)/AC133(+) AC133(+) distance-weighted (CD31(+)/34(+)/45(+)/AC133(+) cells).Living positive early stem marker AC133(+). This may reflect an need vascular repair. Levels these be sensitive index injury because roadways.