Marked Impairment of Endothelium-Dependent Digital Vasodilatations in Patients With Microvascular Angina

• DOI: 10.1161/atvbaha.119.313704
• Publication Date: 2020-04-02T05:00:55Z
• Authors: Shoko Ohura-Kajitani; Takashi Shiroto; Shigeo Godo; Yosuke Ikumi; Akiyo Ito; Shuhei Tanaka; Koichi Sato; Jun Sugisawa; Satoshi Tsuchiya; Akira Suda; Tomohiko Shindo; Shohei Ikeda; Kiyotaka Hao; Yoku Kikuchi; Kotaro Nochioka; Yasuharu Matsumoto; Jun Takahashi; Satoshi Miyata; Hiroaki Shimokawa
• Keywords: Stable angina

Objective: It remains to be elucidated whether and how endothelial functions are impaired in peripheral circulation of patients with coronary functional disorders, such as vasospastic angina (VSA) microvascular (MVA). We simultaneously examined conduit resistance arteries a special reference NO endothelium-dependent hyperpolarization factors. Approach Results: Based on the results invasive acetylcholine testing physiological measurements, we divided 43 into 3 groups; VSA, MVA, VSA+MVA. Endothelium-dependent vasodilatations brachial artery fingertip arterioles intra-arterial infusion bradykinin were evaluated by ultrasonography arterial tonometry, respectively. To assess factors, measurements repeated after oral aspirin N G -monomethyl-L-arginine. Additionally, endothelium-independent sublingual nitroglycerin plasma levels biomarkers for measured. Surprisingly, digital almost absent MVA alone those VSA+MVA compared VSA alone. Mechanistically, both NO- hyperpolarization–mediated markedly In contrast, comparable among groups. Plasma soluble VCAM (vascular cell adhesion molecule)-1 significantly higher Conclusions: These provide first evidence that patients, suggesting is cardiac manifestation systemic small disease.