Response to Letter Regarding Article, “High-Density Substrate Mapping in Brugada Syndrome: Combined Role of Conduction and Repolarization Heterogeneities in Arrhythmogenesis”

03 medical and health sciences 0302 clinical medicine 3. Good health
DOI: 10.1161/cir.0b013e3181d8d4b5 Publication Date: 2010-03-22T20:42:55Z
ABSTRACT
We thank Dr Santangeli et al for their kind interest in our article describing the electrophysiological features of Brugada syndrome. The authors are concerned that we have not excluded structural heart disease, which they propose requires magnetic resonance imaging and cardiac biopsy. However, the early manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) are electrocardiographic and arrhythmic, not structural, anomalies. None of these patients had electrocardiographic or arrhythmic manifestations indicative of ARVC. Moreover, there was no evidence of ARVC in first-degree relatives screened in the clinic, and a contrast echo with detailed right ventricular views was normal in all of the patients with …
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