Abstract 107: Urinary β2 Microglobulin To Creatinine Ratio As A Predictive Factor Of Intravenous Immunoglobulin Resistance

• DOI: 10.1161/circ.131.suppl_2.107
• Publication Date: 2022-03-19T21:06:46Z
• Authors: Takahisa Yoshikawa; Kenji Waki; Kayo Ogino; Mariko Sawada; Tomohiro Hayashi; Yoshio Arakaki
• Keywords: Beta-2 microglobulin

Introduction: The standard dose of intravenous immunoglobulin (IVIG) as initial therapy for patients with Kawasaki disease (KD) is generally 2 g/kg. In our hospital, the IVIG KD 1 g/kg, which augmented according to treatment response, and changed plasma exchange (PE) if over 6 g/kg ineffective. To date, various factors scoring systems predicting resistance have been reported. We evaluated consecutive urinary β2 microglobulin creatinine ratio (β2MG/Cr) data a possible predictive factor resistance. Objectives: clarify whether β2MG/Cr an effective Methods: retrospectively reviewed all who underwent at 6g/kg in hospital from January 1997 2014. Patients recurrent were excluded study. divided into two groups analysis, those did not require PE. Factors including compared across groups. used peak each patient course disease. Results: There 713 treated 28 without 6g/kg. was successful 24 (non-PE group), 4 required PE (PE group). Urinary measured only one non-PE group. significantly higher group (median 119,228 μg/gCr, 69,286-234,290 μg/gCr) 12,270 1,981-210,647 (p=0.001, t-test). exceeded 100,000 μg/gCr % (1 23) 75 (3 4) temporarily coronary artery lesions (dilation or aneurysm) 57 (13 Coronary regressed patients. Conclusion: Our study suggests that measurement useful non-invasive test