Abstract 21264: Age and Gender Related Left Atrial Remodeling With Magnetic Resonance Imaging: Multi Ethnic Study of Atherosclerosis

• DOI: 10.1161/circ.136.suppl_1.21264
• Publication Date: 2022-03-19T22:45:10Z
• Authors: Bharath Ambale Ve...; Seoyoung Hong; Mohammadali Habibi; Daniel Lim; Enpei Wu; Neal Jorgenson; W. Gregory Hundley; Steven J Shea; Kiang Liu; Antoinette S Gomes; Susan Heckbert; Wendy S Post; David A Bluemke; Joao A Lima
• Keywords: Body surface area; Ventricular remodeling; Longitudinal Study

Introduction: Left atrial (LA) structure and function are associated with future cardiovascular (CV) events risk factors. Studying the longitudinal change of LA age may provide important insights into natural history remodeling. Hypothesis: The aim this study is to evaluate associations between gender changes in remodeling a large multi-ethnic cohort free clinical CV disease at baseline. Methods: Cardiac magnetic resonance (CMR) was used identify 2882 MESA participants who underwent baseline (year 2000-2002) 10-year follow-up CMR imaging. Multimodality tissue tracking (MTT, Toshiba) software calculate (LA maximum, minimum pre-atrial contraction volumes indexed body surface area - Vmax, Vmin VpreA) total, passive active emptying fraction, LATEF, LAPEF, LAAEF). Data were analyzed multivariable mixed-effects regression models which outcome measurements, covariates included time factors (hypertension, diabetes, smoking, race/ethnicity, mass index, lipid levels). Results: Participants aged 45-84 years baseline, 53% women. At men had lower LATEF than women (58.4 vs 63.4%, p<0.05), while they similar Vmax (30.3 29.9 ml/m2, p=NS) larger (13.1 11.5 p=NS). Median imaging 9.4 years. Over period, increased both (by 4.8 5.2 ml/m2 respectively, p<0.05) 4.9 4.6 p<0.05); decreased (-7.3 % women, -6.1% men, p<0.05). Conclusions: In population disease, higher as well volumes. Aging volume