Abstract 049: Mitochondrial DNA Copy Number and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study (ARIC)

• DOI: 10.1161/circ.137.suppl_1.049
• Publication Date: 2021-07-02T20:04:45Z
• Authors: Di Zhao; Eliseo Guallar; Ryan Longchamps; Christina Castellani; Yunsoo Hong; Alvaro Alonso; Nathan Pankratz; John Lane; Dan Arking
• Keywords: Rotterdam Study

Background: Atrial fibrillation (AF) is the most common clinical arrhythmia. Molecular studies suggest that mitochondrial dysfunction associated with increased risk of AF through reduced production adenosine triphosphate and reactive oxidative species. Mitochondrial DNA copy number (mtDNA CN), a marker function, has been found to be sudden cardiac death cardiovascular disease (CVD) in ARIC. However, association between mtDNA CN incident general population unknown. Objective: To examine prospective AF. Methods: Cohort study 10,764 ARIC participants without at baseline (1987-89) followed December 31, 2014. were identified electrocardiograms, review hospital discharge codes, certificates. samples isolated from buffy coat. was calculated probe intensities on Affymetrix Genome-Wide Human single nucleotide polymorphisms (SNP) Array standardized using residual method. Cox proportional hazards models adjusted for demographics CVD factors used estimate hazard ratios (HR) comparing four lowest quintiles highest quintile. Results: The mean (SD) age 57.4 (6.0) years. During 21 years median follow-up, 1,946 developed In fully-adjusted models, HRs (95% CI) 1 - 4 quintile 5 1.17 (1.00, 1.37), (0.99, 0.92 (0.78, 1.10) 1.05 (0.89, 1.24), respectively (p-trend 0.044; Figure). HR 10 th vs 90 percentile mtDNA-CN 1.16 (1.04, 1.30). Conclusions: inversely independent traditional factors. Decline function may novel mechanism underlying biological changes increase population. provide potential prevention strategies.