Abstract 14051: The Associations Between Loneliness and Circulating Lipoproteins as Well as Diabetes Risk in African-American Women Residing in Resource-Limited Neighborhoods: Data From the Step It Up Physical Activity Intervention

• DOI: 10.1161/circ.148.suppl_1.14051
• Publication Date: 2023-12-19T07:59:21Z
• Authors: Sandy Reynolds; Yvonne Baumer; Ayushi Dave; Manuel Cintron; Hannatu Tarfa; Mario Pita; Lola Ortiz-Whitti...; Kameswari Potharaju; Andrew Baez; Keitra Thompson; Foster Osei Baah; Colby Ayers; Sam Neally; Kaveri Curlin; Nithya Vijayakumar; Valerie Mitchell; Marie Marah; Billy Collins; Abhinav Saurabh; Maureen Sampson; Alan Remaley; Tiffany M Powell-...
• Keywords: Lipoprotein particle

Background: Loneliness is a public health crisis and recent reports suggest that people suffering from loneliness have increased cardiovascular disease (CVD) risk. A potential link between CVD an atherogenic shift in the lipoprotein profile. We investigated associations lipoproteins African American (AA) women residing resource-limited neighborhoods of Washington, DC. Methods: Participants were enrolled Step It Up, technology-based, community-engaged PA intervention. Fasting blood samples drawn at baseline to measure using nuclear magnetic resonance (NMR) technology. The Lipoprotein Insulin Resistance Index (LP-IR), diabetes risk marker, was calculated. measured UCLA scale. Associations loneliness, particles LP-IR analyzed multivariable regression adjusted for BMI, ASCVD 10-year score, lipid-lowering therapy. Results: 106 AA with (Age 55.9±13, BMI 36.3±6.7) into Up. found higher associated Apo-B, LDL concentration (LDL-c), particle number (LDL-p) but not size (LDL-z, Table). observed triglyceride rich (TRL-z). This relationship seems be due very large TRL (TRL-p, No significant HDL-related measures. Lastly, significantly LP-IR, new marker (Table). Conclusions: Thus, our data show under resourced hyperlipidemia highlights mechanism by which may accelerate support urgent need multilevel interventions reduce at-risk populations.