Abstract 17254: Myocardial Functional Recovery Following Durable Ventricular Assist Device in Children

• DOI: 10.1161/circ.148.suppl_1.17254
• Publication Date: 2023-12-19T08:08:02Z
• Authors: Bhavikkumar Langa...; Osami Honjo; Alyssa Power; Mjaye Mazwi; Oshri Zaulan; Aine Lynch; Christoph Haller; Kristen George; Linda Fazari; Andrea Maurich; David Chiasson; Aamir Jeewa
• Keywords: Pulsatile flow; Dilated Cardiomyopathy; Ischemic Cardiomyopathy

Introduction: Ventricular Assist Device (VAD) explantation following myocardial functional recovery (MFR) for heart failure (HF) is uncommon and associated with a risk of recurrence HF. Research Question: What are the patient characteristics outcomes VAD in children MFR? Methods: Retrospective, single centre study patients who were supported durable VADs, both intracorporeal continuous flow devices (CFD) paracorporeal pulsatile (PFD) between 2004 to 2022. Results: A total 75 children, which 43 female, underwent implantation (PFD = 61 CFD 14) at median (IQR) age 5.6 (0.8, 13.5) years weight 16.2 (7.5, 40.7) kg. From this cohort, we identified 8/75 (11%) MFR after duration 56 (22, 115) days. All PFD. Five listed transplantation as part their HF management strategy four had dilated cardiomyopathy (DCM). Of those, 7/8 (88%) under 2 5/8 (63%) > 90 The pathological findings on LV core samples variable severity no any evidence active inflammation (see Table). After explant, remained remission symptoms stable function. One demonstrating while support. This was 5 old implant ~9 months explant before recurrence, requiring re-implantation eventual transplantation. Conclusions: resulting feasible chronic especially those < age. Further work needed help better identify features that promote maintain it explant.