Abstract 17536: Real World Analysis from the "Fast STEMI" Registry on Adherence and Discontinuation of Statin Therapy Within 6 Months After ST-Elevation Myocardial Infarction on First Year Follow-Up: Prognostic Impact and Predictors of Adherence

• DOI: 10.1161/circ.148.suppl_1.17536
• Publication Date: 2023-12-19T08:12:47Z
• Authors: arianna morena; Federico Giacobbe; Umberto Annone; Emanuele Ravetti; umberto di vita; Giuseppe Giannino; Mattia Troncone; Ludovica Carmagnola; Veronica Dusi; Marco Nebiolo; Ovidio De Filippo; Francesco Bruno; Fabrizio D'Ascenzo; Massimo Giammaria; Gaetano Maria De ...
• Keywords: Discontinuation; Stroke; Univariate analysis

Background: The impact of statin therapy on cardiovascular outcomes after ST-elevation acute myocardial infarction (STEMI) in real-world patients is understudied. Objectives: to identify predictors low adherence and discontinuation within 6 months STEMI estimate their at one year follow-up. Methods: We evaluated by comparing the number bought tablets expected ones 1 follow-up through pharmacy registries. A total 6043 admitted from 2012 2017 were enrolled FAST registry followed up for 4,7±1,6 years; 299 with intraprocedural intrahospital deaths excluded. main all-cause death, infarction, major minor bleeding events, ischemic stroke. compliance cut-off chosen was 80% as mainly reported literature. Results: From a 5744 patients, 418 (7,2%) interrupted STEMI. After univariate multivariate analysis age over 75 years old, known cardiopathy female gender resulted discontinuation. Statin showed an increase both (5% vs 1.7%; HR 2.23; 95%CI 1.37-3.65; p=0,001) mortality (14.8% 5.1%, 2.32; 1.73-3.11; p<0,001) Regarding outcomes, optimal (>80%) reduced stroke incidence (1% 2.5%, p=0.001) death (0.1% 4.6%; 0.3% 13.4%; p<0.001) Age chronic renal failure, previous atrial fibrillation, vasculopathy, found be adherence. Conclusions: In our independently associated Low led higher rates This confirmed predictive factors already described